PRP Therapy for Fertility — emerging, not magic.

What is PRP?

PRP (platelet-rich plasma) is a small volume of plasma in which the platelet concentration has been increased several-fold by laboratory processing. Platelets carry growth factors — small signalling proteins (VEGF, PDGF, TGF-β, EGF) that support cell proliferation, vascular development, and tissue repair. When concentrated PRP is injected into a tissue, those growth factors are delivered locally, in a much higher dose than the body normally provides.

In fertility, PRP is used in two main contexts: ovarian PRP for diminished ovarian reserve (where the goal is to wake up dormant follicles), and intrauterine PRP for thin endometrium or refractory Asherman syndrome (where the goal is to thicken and revascularise a lining that hasn't responded to standard hormonal preparation).

Ovarian PRP — for diminished ovarian reserve

Under ultrasound guidance, PRP is injected directly into the ovarian cortex. The hypothesis is that local growth factors stimulate dormant primordial follicles to activate — potentially restoring some ovarian function in women with low AMH or even premature ovarian insufficiency.

The reality, honestly: evidence is encouraging but not conclusive. Several small studies report:

• Resumed ovulation in some women with previously absent cycles.
• Modest AMH improvement.
• Occasional spontaneous pregnancies after PRP.

We don't yet know which patients are most likely to benefit, how long benefit lasts, or whether the effect is real on a population scale. Larger randomised trials are still needed.

Intrauterine PRP — for thin endometrium and Asherman

PRP is instilled into the uterine cavity through a thin catheter, similar to an IUI procedure. The hypothesis: growth factors directly stimulate the endometrial cells, improving thickness, vascularity, and receptivity.

The evidence here is more consistent. Multiple studies show:

• Measurable increase in endometrial thickness (typically 1–2 mm) in women with refractory thin endometrium.
• Higher subsequent embryo transfer pregnancy rates in patients whose lining had not responded to standard protocols.
• Encouraging results in Asherman syndrome alongside hysteroscopic adhesiolysis.

Intrauterine PRP for thin endometrium has stronger evidence than ovarian PRP for diminished reserve. Both are still considered emerging therapies.

How PRP is prepared — step by step

1. Blood draw — 20–60 mL of peripheral blood drawn into an anticoagulant tube.
2. Centrifugation — separates plasma (top), platelet-poor plasma (middle), and red cells (bottom).
3. Concentration — the platelet-rich layer is isolated. Final PRP volume is typically 3–6 mL.
4. Application — either ovarian injection under ultrasound guidance (ovarian PRP) or intrauterine instillation (uterine PRP) on a scheduled day of the cycle.

Cost in Hyderabad

Ovarian PRP: ₹25,000–₹50,000 per session in Hyderabad in 2026, including processing, anaesthesia, and ultrasound-guided injection. Intrauterine PRP: ₹10,000–₹20,000 per cycle.

Limitations and risks

• Evidence is preliminary. Most studies are small and short-term.
• Not every woman benefits. We can't yet predict who will.
• Procedure risks are low — the materials are from your own blood, so there's no immune or infectious risk from a donor. Procedural risks (bleeding, infection from the injection itself) are very low with good technique.
• Does not reverse menopause. Realistic counselling matters.

How I work

I offer PRP selectively, after honest conversation about the evidence and your specific picture. For diminished ovarian reserve in a younger woman with declining AMH, ovarian PRP can be reasonable to try before donor eggs. For refractory thin endometrium after multiple failed IVF cycles, intrauterine PRP often has better evidence than another standard cycle.

What I won't do: market PRP as a guaranteed solution, charge for repeated sessions without clear evidence of response, or pretend the evidence is more settled than it is.